| 摘要 |
Compounds of general formula (I): A) A compound of general formula (I) Y-AA1-AA2-AA3-AA4-R-Glu-NH2, Y-A1-A2-A3-A4-R-Glu-NH2 wherein Y and R are reporter groups; A1 is either the D-isomer or the L-isomer form of isoleucine; each of A2 and A3 is independently Ala or 2-aminobutyric acid (Abu); A4 is Pro, L-3-hydroxyproline (Pro(3-OH)), L-4-hydroxyproline (Pro (4-OH)), L-tetrahydroisoquinoline-1-carboxylic acid (THIQ), L-tetrahydroisoquinoline-3-carboxylic acid (Tic), L-pipecolic acid (Pip), 1-amino-1-cyclopentane carboxylic acid (1-ACP) or D-Pro; and any one of A1, A2, A3 and A4 can be replaced by any other amino acid group (Xaa); and the other protein based substrates are cleavable by Staphyococcus sp. extracellular cysteine protease and are therefore likely to be of use in monitoring enzyme activity for purposes such as investigating candidate enzyme modulators and screening for therapeutic agents. |
