发明名称 |
TIE-2 ligands, methods of making and uses thereof |
摘要 |
The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.
|
申请公布号 |
US2003166857(A1) |
申请公布日期 |
2003.09.04 |
申请号 |
US20020179615 |
申请日期 |
2002.06.24 |
申请人 |
DAVIS SAMUEL;BRUNO JOANNE;GOLDFARB MITCHELL;ALDRICH THOMAS H.;MAISONPIERRE PETER C.;RADZIEJEWSKI CZESLAW;JONES PAMELA F.;YANCOPOULOS GEORGE D. |
发明人 |
DAVIS SAMUEL;BRUNO JOANNE;GOLDFARB MITCHELL;ALDRICH THOMAS H.;MAISONPIERRE PETER C.;RADZIEJEWSKI CZESLAW;JONES PAMELA F.;YANCOPOULOS GEORGE D. |
分类号 |
A61K38/00;C07H21/04;C07K14/515;C07K14/705;C12N5/06;C12P21/02;(IPC1-7):C07K14/705 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|