THE F-BOX PROTEIN hCdc4 TARGETS CYCLIN E FOR UBIQUITINYLATION AND DEGRADATION

摘要

The present invention provides compositions including polypeptides useful for regulating the cell cycle, proliferation, tumorigenesis, and genomic stability, mutants of such polypeptides useful in identifying abnormal cells and diagnosing disease, antibodies useful for identifying the polypeptides, and polynucleotides that encode the polypeptides.