| 发明名称 |
RRP sequences and knockout mice and uses thereof |
| 摘要 |
RRP genes are identified as modulators of the p53 or p21 pathway, and thus are therapeutic targets for disorders associated with defective p53 or p21 function. Methods for identifying modulators of p53 or p21, comprising screening for agents that modulate the activity of RRP are provided. Modulating agents identified using the methods of the invention can be used to specifically inhibit growth of tumor cells that overexpress an RRP protein. mRRP1 knockout mice are also provided.
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| 申请公布号 |
US2003165497(A1) |
申请公布日期 |
2003.09.04 |
| 申请号 |
US20020056790 |
申请日期 |
2002.01.23 |
| 申请人 |
LIOUBIN MARIO N.;FRIEDMAN LORI;BELVIN MARCIA;LARSON JEFFREY S.;CHEN CHANGYOU;ROBERTSON STEPHANIE A.;SHI WEN;CHAN JOCELYN;LI DANXI;FRANCIS-LANG HELEN;PLOWMAN GREGORY D.;FUNKE ROEL P.;SCHOOR MICHAEL;ZEVNIK BRANKO;KAUSELMANN GUNTHER;TINTRUP HARTMUT |
发明人 |
LIOUBIN MARIO N.;FRIEDMAN LORI;BELVIN MARCIA;LARSON JEFFREY S.;CHEN CHANGYOU;ROBERTSON STEPHANIE A.;SHI WEN;CHAN JOCELYN;LI DANXI;FRANCIS-LANG HELEN;PLOWMAN GREGORY D.;FUNKE ROEL P.;SCHOOR MICHAEL;ZEVNIK BRANKO;KAUSELMANN GUNTHER;TINTRUP HARTMUT |
| 分类号 |
A01K67/027;A61K31/7088;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P35/00;C07K14/705;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12P21/02;C12P21/08;C12Q1/02;C12Q1/37;C12Q1/42;C12Q1/48;C12Q1/527;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/573;G01N33/574;G01N33/68;(IPC1-7):G01N33/574 |
主分类号 |
A01K67/027 |
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