CIRCADIAN CONTROL OF STEM/PROGENITOR CELL SELF-RENEWAL AND DIFFERENTIATION AND OF CLOCK CONTROLLED GENE EXPRESSION

摘要

Methods of controlling bone marrow cell development, stem cell self-renewal, differentiation and/or function, and expression of clock controlled genes having an E-box sequence in their regulatory region by providing appropriate cells having a circadian clock system and manipulating the circadian clock system under conditions effective to control bone marrow cell development, stem cell self-renewal, differentiation and/or function, as well as expression of clock controlled genes having an E-box sequence in their regulatory region. In addition, an in vitro engineered tissue is disclosed that includes a plurality of cells or cell types in intimate contact with one another to form a tissue, the cells or cell types having a circadian clock system that has been modulated to regulate growth, development and/or functions of the cells or cell types within the tissue.