METHOD OF USING MODIFIED OLIGONUCLEOTIDES FOR HEPATIC DELIVERY
摘要
A method of modulating the expression of a nucleic acid in the hepatic system of a mammal is disclosed. In addition, a method of preferentially targeting an oligonucleotide to liver cells in a mammal is disclosed. Also, a method of treating an animal having a hepatic disease or disorder associated with a protein encoded by a gene is disclosed. A composition containing an oligonucleotide is disclosed.
申请公布号
WO03072711(A2)
申请公布日期
2003.09.04
申请号
WO2003US05066
申请日期
2003.02.21
申请人
ISIS PHARMACEUTICALS, INC.;COOK, PHILLIP, DAN;MANOHARAN, MUTHIAH;BENNETT, FRANK, C.
发明人
COOK, PHILLIP, DAN;MANOHARAN, MUTHIAH;BENNETT, FRANK, C.
