发明名称 |
Methods and compositions for genetically modifying primate bone marrow cells |
摘要 |
A method is provided for genetically modifying primate bone marrow cells, comprising isolating bone marrow cells from a primate and, by means which enhance the local concentration of retroviral particles, contacting the isolated bone marrow cells to cells that produce a recombinant amphotropic retrovirus with a genome based on a retroviral vector that contains the genetic information to be introduced into the bone marrow cells. Recombinant amphotropic retrovirus-producing cells, suitable for use in this method also are provided, as are genetically modified primate bone marrow cells with the capacity for regeneration in vivo.
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申请公布号 |
US2003166285(A1) |
申请公布日期 |
2003.09.04 |
申请号 |
US20020164076 |
申请日期 |
2002.06.04 |
申请人 |
VALERIO DOMENICO;VAN BEUSECHEM VICTOR WILLEM |
发明人 |
VALERIO DOMENICO;VAN BEUSECHEM VICTOR WILLEM |
分类号 |
A61K31/70;A61K48/00;A61P7/00;C07K14/15;C12N5/00;C12N5/08;C12N5/10;C12N7/04;C12N9/78;C12N15/00;C12N15/09;C12N15/867;C12R1/91;(IPC1-7):C12N15/867 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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