Method for detecting macromolecular conformational change and binding information

摘要

An active-nucleus sensor or a functionalized active-nucleus complex sensor is utilized in a method for detecting conformational change and binding event information in a targeted molecule, wherein the sensor does not participate in the conformational change or binding event. The method directly or indirectly detects the occurrence, deletion, shift, or any measurable change in a magnetic resonance signal with a unique magnetic resonance property from the active-nuclei, frequently hyperpolarized 129Xe.