发明名称 |
Method for improving genetic stability of foreign insert nucleotide sequence in recombinant single-stranded RNA virus |
摘要 |
The present invention relates to (a) methods for improving a genetic stability of an insert nucleotide sequence in a recombinant single-stranded RNA virus vector, which comprises performing a mutagenesis of the foreign insert nucleotide sequence to provide even distribution of G/C content throughout the overall foreign insert nucleotide sequence and/or to increase G/C content of the foreign insert without substantially causing amino acids substitutions (b) a recombinant single-stranded RNA virus comprising an insert nucleotide sequence with improved genetic stability and (c) a recombinant poliovirus comprising an insert nucleotide sequence with improved genetic stability.
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申请公布号 |
US2003166267(A1) |
申请公布日期 |
2003.09.04 |
申请号 |
US20020071867 |
申请日期 |
2002.02.08 |
申请人 |
LEE SANG-GU;KIM DAE-YOU;KIM KI-TAE;BAE YONG-SOO |
发明人 |
LEE SANG-GU;KIM DAE-YOU;KIM KI-TAE;BAE YONG-SOO |
分类号 |
C12N15/09;C12N7/01;C12N15/64;C12N15/86;C12Q1/70;(IPC1-7):C12N15/86;C12N7/00;A61K39/12;A61K39/21;C12N15/00;C12N15/63;C12N15/70;C12N15/74 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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