| 摘要 |
<p>A chimeric, carboxy-terminal truncated avian hepatitis B virus nucleocapsid protein (AHBc) is disclosed that is engineered for both enhanced stability of self-assembled particles and the display of an immunogenic epitope. The display of the immunogenic epitope is displayed in the immunogenic loop of AHBc, whereas the enhanced stability of selfassembled particles is obtained by the presence of at least one heterologous cysteine residue near the carboxy-terminus of the chimer molecule. Methods of making and using the chimers are also disclosed.</p> |
