IODIZED OIL-BASED FAT EMULSION FOR EFFECTIVELY DELIVERING PHYSIOLOGICALLY ACTIVE SUBSTANCE OR DRUGS AND PRODUCTION THEREOF

摘要

PURPOSE: A process of preparing a fat emulsion using oils having higher specific gravity than water as a fat emulsion base material and amphoteric surfactants as an emulsifier is provided. The fat emulsion exhibits excellent expression efficiency in adhesive cell lines as well as in the presence of serum as compared to conventional liposome or squalane-based fat emulsion formulation and thus permits easy in-vitro assay of gene expression efficiency. CONSTITUTION: A fat emulsion comprises: 2 to 30% by weight of oil mixtures comprising iodized oil and one or more glyceride-based oils such as squalene or squalane as a fat emulsion base; 0.01 to 40% by weight of one or more amphoteric surfactants; 0.01 to 10% by weight of hydrophilic polymers, phospholipid combined with hydrophilic polymers or polymerizable phospholipid; 0.01 to 10% by weight of glycerol, soluble peptide or soluble protein; and the balance comprising water. The oil mixtures contain 40% by weight of iodized oil selected from the group consisting of iodized poppy seed oil.