发明名称 |
METHOD FOR PREPARING MICROSOME DISPERSION |
摘要 |
A method for preparing a vesicle dispersion wherein a water-soluble substance is encupsulated in the vesicle, which comprises successively performing: a step of dispersing at least one lipid in an aqueous medium to pre-construct a vesicle dispersion, a step of drying the pre-constructed vesicles to obtain dried vesicles, a step of re-dispersing the dried vesicles in an aqueous solution of the water-soluble substance, and a step of passing the resultant vesicle dispersion through a filter. The method enables the efficient and simple preparation of safe vesicles with a useful substance in high concentration encupsulated therein, with a narrow size distribution, in high yield.
|
申请公布号 |
EP1340494(A1) |
申请公布日期 |
2003.09.03 |
申请号 |
EP20010993393 |
申请日期 |
2001.11.09 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY CORPORATION |
发明人 |
TSUCHIDA, EISHUN;TAKEOKA, SHINJI;SOU, KEITARO;ENDO, TARO;NAITO, YOSHIYASU |
分类号 |
A61K9/127;B01J13/02;(IPC1-7):A61K9/127;A61K47/30;B01J13/04 |
主分类号 |
A61K9/127 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|