发明名称 |
PROCESS FOR THE PREPARATION OF PROTECTED 1-(1-AMINOALKYL)-OXIRANES |
摘要 |
<p>A method is described for the preparation of a compound of formula (formula see on enclosed paper version) where R is a protective group of the amino groups of the amino acids; R' is a C1-C10 alkyl radical, an aryl, an aralkyl or a group ArX(CH2)m; where Ar is an aryl, X=O, S, NR''; R'' is a C1-C5 alkyl or aryl radical and m is an integer between 0 and 5; in which (a) the carboxyl group of a compound of formula (formula see on enclosed paper version) is activated by treatment with a group that is an activator of carboxyl groups; (b) the compound thus activated is made to condense with a trimethylsulphoxonium or tri-methylsulphonium ylide; (c) the keto-ylide thus obtained is reduced by reaction with a ketone-reducing agent; (d) the compound thus obtained is then cyclized to give the compound of formula IV by reaction with a base.</p> |
申请公布号 |
EP1339667(A1) |
申请公布日期 |
2003.09.03 |
申请号 |
EP20010970067 |
申请日期 |
2001.09.27 |
申请人 |
CLARIANT LIFE SCIENCE MOLECULES (ITALIA) S.P.A. |
发明人 |
BERTOLINI, GIORGIO;BELLANI, PIETRO |
分类号 |
C07B61/00;C07C229/36;C07D301/02;C07D303/36;(IPC1-7):C07C229/10;C07C229/14 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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