发明名称 |
IMMUNOGENS FOR THE PRODUCTION OF COCAINE-HYDROLYZING CATALYTIC ANTIBODIES |
摘要 |
Methods are described for the rapid synthesis in satisfactory yield of methyl ecgonine phenylphosphonates as analogues of transition states for the hydrolysis of the benzoyl ester of an ecgonine derivative, namely cocaine, and their linking to carrier proteins, for the purpose of using them as immunogens. The resulting immunogens elicit the formation in experimental animals of antibodies able to promote the hydrolysis of cocaine. Both these catalytic anti-cocaine antibodies and the immunogens themselves are potentially useful for the treatment of individuals seeking to avoid the pharmacological effects of cocaine and in diagnostic applications.
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申请公布号 |
CA2151543(C) |
申请公布日期 |
2003.09.02 |
申请号 |
CA19952151543 |
申请日期 |
1995.06.12 |
申请人 |
GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (THE) |
发明人 |
MEAH, M. YOUNUS;DEN HOLLANDER, NEIL;BARBER, BRIAN H.;KREPINSKY, JIRI J. |
分类号 |
A61K38/00;A61P25/36;C07F9/6561;C07K16/44;G01N33/94;(IPC1-7):C07K14/765;A61K39/385;A61K39/39;A61K39/395;C07K14/435;C07F9/656 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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