| 摘要 |
<P>PROBLEM TO BE SOLVED: To obtain a useful, optically active substance having a plurality of asymmetric centers by ring-opening stereoselectively an achiral, cyclic compound having a symmetric structure with the high selectivity under a mild condition. <P>SOLUTION: The optically active substance is characterized by obtaining an optically active compound as the result of the stereoselective ring-opening of a cyclic substrate having a symmetric structure by reacting an amine nucleophilic reagent in the coexistence of a bidentate coordinated active species having as a ligand a tartaric acid derivative. The amine uncleophilic reagent includes preferably aniline, benzylamine and phenylethylamine, and the tartaric acid derivative of the ligand uses preferably L-tartaric acid dibenzylamide. <P>COPYRIGHT: (C)2003,JPO |
