| 摘要 |
PROBLEM TO BE SOLVED: To provide a means for using granulysin as a medicine for infectious diseases as a result of a more detailed study on granulysin. SOLUTION: In a newly discovered pathway, 15K granulysin, which itself does not show any cytotoxicity, is ingested by a macrophage and is subsequently activated to kill bacteria ingested in the macrophage. By using 15K granulysin as an active ingredient, an effective therapeutic agent for infectious diseases which has few side effects and prevents acquisition of resistance by bacteria, can be provided. COPYRIGHT: (C)2003,JPO
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