| 摘要 |
PURPOSE: A process of preparing smart nano-particles in which a therapeutic drug is uniformly dispersed within nano-particles by introducing the therapeutic drug into the reaction system during emulsion polymerization of the nano-particles and then polymerizing it is provided. The nano-particles selectively concentrate on a target organ such as cancer cells, etc. by enhanced permeation and retention effect, thereby exhibiting treatment improving effect. CONSTITUTION: A therapeutic drug and a monomer are agitated at 50 to 90deg.C with a surfactant to emulsify, the emulsified monomer is polymerized in an emulsion particle to produce nano-particles. The therapeutic drug is one or more photo-treating drugs selected from porphyrin, phthalocyanine and a derivative thereof. The monomer is one or more selected from anhydride, glycolide, lactide, caprolactone and N-vinylcaprolactame. The surfactant is one or more selected from cetyl trimethyl ammonium bromide as a cationic surfactant and sodium dodecyl sulfate as an anionic surfactant.
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