NEW GENE USEFUL FOR DIAGNOSIS AND TREATMENT OF APLASIA OF CORPUS CALLOSUM AND ASPERMATOGENESIS AND USE THEREOF

摘要

PROBLEM TO BE SOLVED: To isolate a gene coding for a new cell adhesion factor and provide a technique concerning the utilization of this gene.

SOLUTION: Aplasia of the corpus callosum or aspermatogenesis is diagnosed by investigating existence or expression of the BT-IgSF gene with use of a primer for PCR or probe for hybridization comprising a DNA coding for a new cell adhesion factor (BT-IgSF) defined in the following (A) or (B) or a partial sequence thereof: (A) a protein comprising the amino acid sequence of the amino acid numbers having a specific sequence; (B) a protein comprising an amino acid sequence represented by amino acid numbers having a specific sequence including substitution, deletion, insertion or addition of one or several amino acids and having a function as a cell adhesion factor.

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