Substituted imidazole neuropeptide Y Y5 receptor antagonists.

摘要

Compounds of the formula Ior a pharmaceutically acceptable salt, solvate or N-oxide thereof, whereinX is =CH- or =N-;Y is H, halogen, trihaloalkyl, alkyl, alkenyl, cycloalkyl, cycloalkyl, SH, -S-alkyl, or -CN.R is alkyl, -CF3, cycloalkyl, heterocycloalkyl, heterocycloalkyl-alkyl, heteroarylalky or adamantyl, or optionally substituted phenyl, phenoxyalkyl, phenylthioalkyl, pyridyl, thienyl, thiazolyl, pyrazinyl, 1,2,5,6-tetrahydropyridine or wherein R<10 and R<11 are hydrogen, alkyl or together form a cycloalkyl, are disclosed, as well as pharmaceutical compositions and methods of using said compounds in the treatment of eating disorders and diabetes.