摘要 |
The use of a compound of formula (I), wherein; X is CO or SO2; Y is H, or optionally substituted alkyl; R1 is H, halo, NO2, N3, CN, SOCH2Y, SO2CH2Y, COCH2Y, SONHY, SO2NHY, CONHY, CO2Y, an optionally substituted alkyl group or the replacement of one -CH= in the aromatic ring with -N=; R2 represents the optional presence of methyl or ethyl; For use in the manufacture of a medicament for the treatment of neoplastic disease in combination with a nitroreductase enzyme. Also described is a two-component system for the treatment of neoplastic disease comprising a compound of formula (I) and a vector encoding and capable of expressing a nitroreductase enzyme in a tumour cell.
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