| 摘要 |
A compound of formulae (I), (II) or (III), wherein: R1, R7 and R8 are independently H, halo, alkyl, haloalkyl and hydroxy, R3 is hydroxy or -OCONH2, and R4 is hydroxy or carbonyl. The compounds are used in the manufacture of medicaments for treating neurological disorders and hypoxic conditions. NZ Patent Office Journal 1490 published on 29 August 2003 - Part 3 (11) 513325 (22) 12 Feb 2000 (54) Phenylalaninol derivatives and their use in treatment (86) PCT/EP00/01168 (87) WO00/48988 (51) IPC7:C07C233/80; C07C235/40; C07C317/44; C07C323/60; A61K31/167; A61P29/00 (71) F. HOFFMANN-LA ROCHE AG (72) Sidduri, Achytharao; Tilley, Jefferson Wright; (31) 99 120498 (32) 18 Feb 1999 (33) US (74) A J PARK, 6th Floor, Huddart Parker Building, 1 Post Office Square, Wellington, New Zealand (57) A compound of formula (I); where: X is a group of the formula X-1, X-2 or X-3. Y is a group of formula Y-1 or Y is a group Y-2 (which is a five or six membered heteroaromatic ring bonded via a carbon atom to the amide carbonyl wherein the ring contains one, two or three heteroatoms selected from the group consisting of N, O and S and one or two atoms of said ring are independently substituted by lower alkyl, cycloalkyl, halogen, cyano, perfluoroalkyl, or aryl and at least one of said substituted atoms is adjacent to the carbon atom bonded to the amide carbonyl); or Y is group Y-3, Y-4, Y-5 or Y-6. Also described is a pharmaceutical composition comprising the compound of formula (I). The compound of formula (I) is useful for the treatment or prophylaxis of illnesses, especially rheumatoid arthritis, multiple schlerosis, inflammatory bowel disease, and asthma.
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