发明名称 Novel naphthalene ureas as glucose uptake enhancers
摘要 A compound of formula I, wherein: R1 and R2 are independently selected from -SO2NR72, -C(O)NR72, -NR7SO2R7, -NR7C(O)R7, -SO2OR7, -C(O)OR7, -OSO2R7, or -OC(O)R7, R5 and R6 are independently hydrogen, alkyl, cyano, halo, nitro, -SR8, -C(O)R8, -SO2OR8, -OSO2R8, -SO2NR82, -NR8SO2R8, -OC(O)R8, -C(O)OR8, -C(O)NR82, -NR8C(O)R8, -OR8, or -NR82, Y is independently alkyl, cyano, halo, nitro, -SR, -OR, or -NR2, x is independently 0, 1 or 2, and the linker is a heteroatom-containing chain described herein. The compounds are used in the manufacture of medicaments for the treatment of hyperglycemia, type I diabetes and type II diabetes.
申请公布号 NZ515743(A) 申请公布日期 2003.08.29
申请号 NZ20000515743 申请日期 2000.05.25
申请人 TELIK, INC 发明人 SPEVAK, WAYNE;LUM, ROBERT T;SHI, SONGYUAN;MANCHEM, PRASAD;KOZLOWSKI, MICHAEL R;SCHOW, STEVEN R
分类号 C07D233/32;A61K31/18;A61K31/216;A61K31/255;A61K31/41;A61K31/4166;A61K31/4406;A61K31/445;A61K31/4965;A61K31/505;A61K31/662;A61P3/10;A61P43/00;C07B59/00;C07C273/00;C07C275/42;C07C303/22;C07C303/30;C07C303/38;C07C309/51;C07C309/58;C07C309/76;C07C309/88;C07C311/21;C07C311/47;C07C335/16;C07C335/18;C07C335/32;C07D211/60;C07D211/96;C07D213/76;C07D233/36;C07D239/42;C07D241/20;C07D257/04;C07F9/40;(IPC1-7):C07C309/00 主分类号 C07D233/32
代理机构 代理人
主权项
地址