| 摘要 |
Process has been described for obtaining compounds of formula (1.3.0) where N is that consists of the preparation of reaction mixture containing (formula) in the aprotonic solvent; in the presence of the strong base in the solid shape that is chosen from the group consisting of (formula) and (formula); and optionally, in the presence of cathalYtic amount of celsium-carbonate or cathalyst of phase transfer, in particular quaternary amonium salt or phosphonium salt, after which follows warning of the mentioned reaction mixture in the atmosphere of nitrogen; therefore obtaining compound of the formula (1.3.0), and in the desirable realization aprotonic solvent is DMSO, strong base in the solid form is NaOH in the shape of powder of pellets, and in the cathalyst of phase transfer is tetra-n-amonium chloride (TBAC), which is used for obtaining compounds that are useful as inhibitor of 5lipoxygenase, of a formula and, in particular, it is essentially pure methanol sulphate salt. |
