发明名称 |
Composition comprising a process of forming dried core particle topiramate coated with a taste masking substance followed by a binder further coated with a further taste masking substance and method for treating epilepsy and convulsions |
摘要 |
A pharmaceutical composition can be formed by preparing core particles comprising the active agent topiramate, drying the particles to form dried core particles and then coating the dried particles with a taste masking mixture to form coated particles. The coated particles are then dried to form the composition. The amount of the taste masking agent ranges from about 7% to about 15% by weight of the pharmaceutical composition. Also described is a pharmaceutical composition comprising core particles having an initial particle size of between 0.1 mm and 2.5 mm and a taste masking coating that comprises about 7% to about 15% by weight of the composition. The composition can comprise 85 to 93% by weight core beads and 7 to 15% by weight of coating. The core beads comprise 18 to 21% by weight of topiramate and 8-11% by weight of povidone and 58 to 61% by weight of sugar. The coating comprises 6-9% by weight of cellulose acetate and 2 to 5% by weight of povidone. The compositions can be used for treating convulsion or epilepsy.
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申请公布号 |
NZ506532(A) |
申请公布日期 |
2003.08.29 |
申请号 |
NZ19990506532 |
申请日期 |
1999.03.01 |
申请人 |
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发明人 |
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分类号 |
A61K9/16;A61K9/28;A61K9/58;A61K9/62;A61K31/357;A61K31/7048;A61K47/26;A61K47/30;A61K47/32;A61K47/36;A61K47/38;A61P25/08;(IPC1-7):A61K9/26;A61K31/18 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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