Multi-component vaccine comprising at least two antigens from Haemophilus influenzae to protect against disease

摘要

An immunogenic composition comprises at least two different antigens of Haemophilus influenzae. At least one of the antigens is an adhesin and the other antigen is not an adhesin. Also described is a composition comprising a analog of Haemophilus influenzae Hin47 protein having a decreases protease activity, of which the activity is less than about 10% of natural Hin47, and a high molecular weight (HMW) protein of a strain of a non-typeable Haemophilus influenzae. The compositions can be used as a vaccine for conferring protection against disease caused by infection with Haemophilus influenzae including otitis media.