Improvements in the enzymatic synthesis of chiral amines

摘要

The stereoselective synthesis of a chiral amine; wherein a ketone is brought into contact with a transaminase in the presence of an amino donor. The carbonyl group of the ketone is bound either to two substituents that differ from each other in structure or chirality, or to a divalent group that together with the carbonyl group constitutes a chiral cyclic structure comprising 2-aminopropane as the amine donor. Included is a method of preparing (S)-1-methoxy-2-aminopropane.