CD40 SPLICE VARIANTS, COMPOSITIONS FOR MAKING AND METHODS OFUSING THE SAME

摘要

Substantially pure CD40 splice variants which include unique tail sequences, fragments thereof comprising at least 10 amino acids including at least 4 amino acids of the unique tail sequence; the unique tail sequences, and homologues thereof having at least 10 amino acids and 90% identity and antibodies which bind to an epitope on such proteins are disclosed. Pharmaceutical composition comprising such protein, antibodies, isolated nucleic acid molecule that encode such proteins and pharmaceutical compositi on comprising such nucleic acid molecules are disclosed. The present invention relates to recombinant expression vectors which comprise such nucleic acid molecules and host cells which comprise such recombinant expression vectors are disclosed. In vitro methods of detecting in a sample the presence and/or quantity of such proteins or transcript which encodes such proteins are disclosed as are kits and reagents for performing the methods. Methods of modulating CD40-CD154 interactions in an individual are disclosed.