Antibodies to polypeptide molecules of the G protein-coupled heptahelical receptor superfamily and uses therefor

摘要

Novel D6 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length D6 proteins, the invention further provides isolated D6 fusion proteins, antigenic peptides and anti-D6 antibodies. The invention also provides D6 nucleic acid molecules, recombinant expression vectors containing nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a D6 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.