LIQUID MUCOADHESIVE PHARMACEUTICAL COMPOSITION

摘要

The present invention relates to liquid mucoadhesive pharmaceutical composition to be applied to the mucosal epithelia with prolonged and improved coating and protection effect. The composition can be used in the medical practice as oral, ocular, nasal, rectal, vaginal and periodontal pharmaceutical preparations. The liquid pharmaceutical composition comprises xylomethazoline.HCl about 0.10 wt.% to 10.00 wt.%, hydroxypropyl methycellulose from 0.01 wt.% to 10 wt.%, disodium ethylenediamine tetraacetate from 0.01 wt.% to 10.00 wt.%, phosphate buffer to 100 wt. % with pH about 5 to 7, the relative viscosity of the solution is about 70.00 to 90.00, and the relative adhesive capacity is 105.0 % to 120.0 %. The composition according to the invention can be applied easilly and has a prolonged contact to the mucosal surface. In this way the composition provides a good therapeutic effect at lower does and has a good bioavailability.