COMPOSITIONS AND METHODS FOR THE SYNTHESIS AND SUBSEQUENT MODIFICATION OF URIDINE-5'-DIPHOSPHOSULFOQUINOVOSE (UDP-SQ)

摘要

The present invention is directed to composition and methods related to the synthesis and modification of uridine-5'-diphospho-sulfoquinovose (UDP-SQ).In particular, the methods of the present invention comprise the utilization of recombinant enzymes from Arabidopsis thaliana, UDP-glucose, and a sulfur donor to synthesize UDP-SQ, and the subsequent modification of UDP-SQ to form compounds inlcuding, but not limited to, 6-sulfo-a-D-quinovosyl diaclyglycerol (SQDG) and alkyl sulfoquinovoside. The compositions and methods of the invention provide a more simple, rapid means of synthesizing UDP-SQ, and the subsequent modification of UDP-SQ to compounds including, but not limited to, SQDG.