| 摘要 |
A peptide component (A) represented by the following formula (1a) with a peptide component (B) represented by the following formula (2a) and a compound (C) represented by the following formula (3a), as an optional component are subjected to a condensation reaction in the presence of a dehydrating and condensing agent and a condensing auxiliary; provided that in the case where "X" represents HOOC- (CH2)m-CO- in the formula (1a) and/or (2a), the reaction is conducted with the compound (C). The ratio of the peptide component (A) relative to the peptide component (B) is 100/0 to 30/70 (mol%), and the ratio of the compound (C) relative to the total molar amount of the peptide component (A) and/or the peptide component (B). X-(Pro-Y-Gly)n-OH (1a), X-(Z)r-OH (2a), H2N-R-NH2 (3a) Wherein "X" represents H or the group HOOC- (CH2)m-CO- ("m" = 1 to 18), "Y" represents Pro or Hyp, "n" = 1 to 20, "Z" represents a peptide chain comprising 1 to amino acid residue(s), "r" = 1 to 20, and "R" represents a linear or branched alkylene group. The present invention provides a collagenous polypeptide which is free from a risk of an infection by a pathogenic organism (or a causative factor) or an undesirable side effect, and which has a high safety.
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