A METHOD FOR DETERMINING THE THERAPEUTIC EFFECTIVENESS OF A SUBSTANCE USING A MICROPHYSIOMETER AND USE OF THE METHOD

摘要

This invention is related to a method for determining the therapeutic effectiveness of a substance using a microphysiometer. It has been found that more accurate results can be achieved by incorporating a statistical model for tumour cells survival under treatment from a chemotherapeutic substance. The statistical model is used in combination with cell metabolic activity measurements obtained using a microphysiometer in order to provide a more accurate and robust method for determining the therapeutic effectiveness of a substance on tumourous cells. The invention also relates to use of the method for improving an objective quantitative measure of chemosensitivity, preferably of tumour cells.