摘要 |
Provided herein is an in vitro granuloma model and methods of its use. Methods of detecting and/or diagnosing latent tuberculosis in a subject are also provided, as are latency-specific antigens (and antibodies thereto), such as alpha-crystallin, and methods of identifying and using such molecules. Also provided are immunostimulatory compositions, for instance for use in eliciting an immune response in a subject, such as an immune response to a latent tuberculosis infection. Kits for carrying out the provided methods are also described. |
申请人 |
THE GOVERNEMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION;QUINN, FREDERICK, D.;BIRKNESS, KRISTIN, A.;DESLAURIERS, MANON;KING, PETER;BEALL, DAVID, S. |
发明人 |
QUINN, FREDERICK, D.;BIRKNESS, KRISTIN, A.;DESLAURIERS, MANON;KING, PETER;BEALL, DAVID, S. |