| 摘要 |
<p>The present invention concerns methods and reagents useful in modulating gastric inhibitory polypeptide (GIP) and gastric inhibitory polypeptide receptor (GIPr) gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against gastric inhibitory polypeptide (GIP) and gastric inhibitory polypeptide receptor (GIPr) gene expression and/or activity. The small nucleic acid molecules are useful in the treatment of obesity, insulin resistance and/or diabetes, and any other condition that responds to modulation of GIP and/or GIPr expression or activity.</p> |
