| 摘要 |
Microbiological preparation of mycophenolic acid and its derivatives (I) comprises growing a Penicillium waksmanifungal strain able to biosynthesize mycophenolic acid on a culture medium containing assimilable carbon and nitrogen sources and mineral salts at 22-30[deg]C. Microbiological preparation of mycophenolic acid and its derivatives of formula (I) comprises growing a Penicillium waksmanifungal strain able to biosynthesize mycophenolic acid on a culture medium containing assimilable C and N sources and mineral salts at 22-30[deg]C, separating (I; R 1= Me; R 2= OH) from the fermentation broth and optionally purifying and bioconverting it by: (a) by using the cultures of Streptomyces griseoruberNo. 1/6 actinomycete strain deposited at the National Collection of Agricultural and Industrial Microorganisms as Streptomyces sp.No. 1/6 under No. NCAIM (P)B 001275 to prepare (I; R 1= Me or CH 2OH; R 2= NH 2) or (b) by using the cultures of Streptomyces resistomycificusNo. 1/28 actinomycete strain deposited at the National Collection of Agricultural and Industrial Microorganisms under No. NCAIM (P)B 001276 to prepare (I; R 1= CH 2OH; R 2= NH 2) on a culture medium containing assimilable C and N sources and mineral salts under submerged, aerated conditions upto completion of the bioconversion, separating (I) formed from the culture and optionally purifying it. [Image] R 1Me or CH 2OH; R 2OH or NH 2. An independent claim is also included for compounds (I), where: R 1Me or CH 2OH, and R 2NH 2. ACTIVITY : Antibacterial; antifungal; immunosuppressant; antiviral.. MECHANISM OF ACTION : Inosine-5'-monophosphate dehydrogenase inhibitor; guanine-5'-monophosphate synthetase inhibitor. No biological data is given. |
