发明名称 |
GENE EXPRESSION DATA ANALYZER, AND METHOD, PROGRAM AND RECORDING MEDIUM FOR GENE EXPRESSION DATA ANALYSIS |
摘要 |
Gene expression doses expressed in fluorometric data, which are measured by an experiment with the use of DNA microarrays and DNA chips, of a comparative group and a control group are corrected based on a novel mathematic model. Based on the scatter plots thus corrected, a novel X-Y axis system having an x axis proprotional to the fluorescence intensity of genes is constructed. Next, windows each having a definite number of genes are made along the X-axis and the reliability limit of the arbitrary risk is determined in each window in accordance with Student's t-distribution. Then windows are shifted by a definite number of genes in the X-axis direction and each reliability limit is determined. The plural reliability limits thus determined are complemented by smoothening (spline curve) to give a reliability curve of expression variation. Subsequently, genes located outside the reliability curve of expression variation thus obtained are extracted as variation genes.
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申请公布号 |
WO03070938(A1) |
申请公布日期 |
2003.08.28 |
申请号 |
WO2003JP01900 |
申请日期 |
2003.02.21 |
申请人 |
AJINOMOTO CO., INC.;ONO, NOBUKAZU;TAKAHARA, YOSHIYUKI;ZHANG, QUINGWEI;TANAKA, HIROSHI |
发明人 |
ONO, NOBUKAZU;TAKAHARA, YOSHIYUKI;ZHANG, QUINGWEI;TANAKA, HIROSHI |
分类号 |
C12M1/00;C12M1/34;C12N15/09;C12Q1/68;G01N33/53;G01N37/00;G06F17/30;G06F19/00;(IPC1-7):C12N15/09 |
主分类号 |
C12M1/00 |
代理机构 |
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代理人 |
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地址 |
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