| 摘要 |
<p>There is drawn a novel hypothesis on a novel intracellular signaling mechanism that though no phosphorylation arises in the C-terminal domain in a receptor cell, an unknown molecule would associate to the Pro-C terminal domain of a G protein-coupled receptor to a chemokine to thereby inhibit the receptor-dependent leukocyte migration. By discussing this hypothesis, attempts were made to search for a CCR2-binding protein to thereby clarify a novel target in treating inflammatory diseases and other various diseases. As a result, a novel cellular protein associating directly and specifically to the Pro-12-C terminal domain of CCR2 is found out and it is clarified that this protein forms a cluster together with CCR2 after stimulating CCL2. Thus, the presence of a novel signaling system is clarified in the CCL2-CCR2 pathway in addition to the known G protein-mediated intracellular signaling systems. It is also found out that this novel protein associates to the C-terminal domain in a cell of a receptor CCR5.</p> |
