| 摘要 |
1. The use of lactadherin or a variant thereof, for the preparation of a composition for regulating the immune response. 2. The use according to claim 1, for the inhibition of the cross-priming of antigens. 3. The use according to claim 2, of a variant of lactadherin lacking a functional phospolipid binding site and/or a functional integrin binding site. 4. The use according to claim 1, for the stimulation of the phagocytosis of antigens by dendritic cells. 5. The use according to claim 1, for the stimulation of the cross-priming of antigens. 6. The use of lactadherin or a variant thereof, for the preparation of a composition for the delivery of a molecule to a dendritic cell. 7. The use according to any one of the preceding claims, wherein the lactadherin or variant thereof is human lactadherin or a variant thereof. 8. An immunogenic composition comprising lactadherin or a variant thereof in association with an antigen or cytokine. 9. The composition according to claim 8, wherein said antigen or cytokine is covalently associated to the lactadherin or variant thereof. 10. The composition according to claim 8, comprising a liposome, wherein said liposome comprises lactadherin or a variant thereof covalently associated with in association with antigen or cytokine. 11. An immunogenic composition comprising lactadherin or a variant thereof in association with an antigen. 12. The composition according to claim 11, wherein antigen is protein, polypeptide, peptide, virus or bacteria. 13. A chimeric protein comprising lactadherin or a variant thereof fused to immunogen or immunostimulant polypeptide. 14. A nucleic acid encoding a protein according to claim 13. 15. A liposome comprising a recombinant lactadherin or variant thereof. 16. An immunogenic composition comprising a chimeric protein according to claim 13 or a liposome according to Claim 15. 17. A recombinant virus expressing lactadherin as a surface molecule. 18. A recombinant cell expressing lactadherin as a surface molecule.
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