NOVEL NUCLEOSIDES WITH BICYCLIC SUGAR MOIETY AND OLIGONUCLEOTIDES COMPRISING THEREOF

摘要

FIELD: organic chemistry, chemistry of nucleic acids, biochemistry. SUBSTANCE: invention relates to nucleosides of the formula (1) with bicyclic sugar moiety comprising 2',4'-bridging linkage and to oligonucleotides based on thereof. Oligonucleotides show high affinity with respect to nucleic acid-targets and can b used in medicine. EFFECT: valuable medicinal properties of nucleosides. 4 cl, 1 tbl, 35 ex