N-ALKYLGLYCINE TRIMERES CAPABLE OF BLOCKING THE RESPONSE TO CHEMICAL SUBSTANCES, HEAT STIMULI OR MEDIATORS OF NEURONAL RECEPTOR INFLAMMATION AND COMPOSITIONS CONTAINING SAID TRIMERES

摘要

The invention relates to N-alkylglycine trimeres (I), wherein R1 represents 2-(2,4-dichlorophenyl)ethyl, 3-methylbutyl, 2-(methylcarbonylamino)ethyl, 2-(N-imidazolyl)ethyl or 3-(N,N-dimethylamino)propyl; R2 represents 2-(2,4-dichlorophenyl)ethyl, 2-(4-methoxyphenyl)ethyl, 3,3-diphenylpropyl or 3-(N,N-diethylamino)propyl; and R3 represents N,N-diethylaminopropyl, 3,3-diphenyl-propyl or 2-Ä2-(N-methyl)pyrrolidinylÜethyl. Said trimeres are capable of blocking the ionic channels that are activated by exogenous chemical substances, heat stimuli or inflammation mediators, such as nociceptors VR1 and glutamate ionotropic receptors and are useful for treating disorders mediated by the activity of said receptors. <CHEM>