| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a binder/disintegrator for dry direct compressing, having excellent bondability and fluidity. <P>SOLUTION: The low substitution degree hydroxypropylcellulose comprising coiled fiber and having 0.1-0.5 substituted molar number of hydroxypropoxy is provided. The low substitution degree hydroxypropylcellulose preferably has ≥60 flow index and ≥130 N tablet hardness in evaluating fracture strength of a tablet obtained by compression molding of the hydroxypropylcellulose. A binder/disintegrator for dry direct compressing and a solid preparation each containing the hydroxypropylcellulose are provided. A method for producing the low substitution degree hydroxypropylcellulose, characterized by pelletizing a washed low substitution degree hydroxypropylcellulose with a kneader, is provided, wherein the hydroxypropylcellulose comprises the coiled fiber and has 0.1-0.5 substituted molar number of hydroxypropoxy. <P>COPYRIGHT: (C)2003,JPO |
