| 摘要 |
Nucleic acids (I) that encode the human KDR receptor comprising a sequence of 1065 base pairs (bp), its soluble forms comprising sequences of 213 bp, 408 bp, or 501 bp, the murine KDR receptor comprising a sequence of 1032 bp, or its soluble forms comprising sequences of 195 bp,420 bp, or 489 bp, and also their derivatives, fragments and complements, are new. All sequences are fully defined in the specification. Independent claims are also included for the following: (1) KDR receptors (II), also their soluble forms, variants and fragments, produced by expressing (I); (2) Antibodies (Ab) directed against (I) or (II); (3) Cell line that overexpresses a KDR receptor; (4) Transgenic animal that overexpresses (gain of function) or has a genetic deficiency or defect (loss of function) for this receptor; (5) Producing KDR receptors by chemical synthesis or recombinant expression, preferably in eukaryotes; (6) Diagnostic method; and (7) Drug screening. |
