发明名称 |
SUBSTANCE INHIBITING THE BINDING OF SIGNAL TRANSDUCING MOLECULE TO KDR/FLK-1 PHOSPHORYLATED AT TYROSINE AT THE 1175-POSITION AND METHOD OF USING THE SAME |
摘要 |
The present invention provides a substance which inhibits binding of a signal transduction molecule to 1175-tyrosine phosphorylated KDR/Flk-1 and inhibits cell growth by VEGF. Also, the present invention provides a method for inhibiting KDR/Flk-1 signal transduction, a method for inhibiting cell growth, a method for inhibiting angiogenesis, a method for screening a cell growth inhibitor, a method for screening an angiogenesis inhibitor, a method for screening a substance which inhibits KDR/Flk-1 signal transduction, a method for determining whether or not a tested substance can inhibit KDR/Flk-1 signal transduction, a method for detecting angiogenesis in tissue and a method for screening a substance which inhibits 1175-tyrosine phosphorylated. KDR/Flk-1, in which each method comprises using the substance. |
申请公布号 |
EP1338655(A1) |
申请公布日期 |
2003.08.27 |
申请号 |
EP20010972658 |
申请日期 |
2001.10.02 |
申请人 |
KYOWA HAKKO KOGYO CO., LTD;SHIBUYA, MASABUMI |
发明人 |
SHIBUYA, MASABUMI;TAKAHASHI, TOMOKO;FURUYA, AKIKO;SHITARA, KENYA |
分类号 |
A61P9/00;A61P35/00;A61P43/00;C07K16/28;C12Q1/48;(IPC1-7):C12Q1/02;C12N15/09;C07K16/18;C07K14/47;A61K39/395;A61K45/00;G01N33/15;G01N33/50 |
主分类号 |
A61P9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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