PGD2 RECEPTOR ANTAGONISTIC PHARMACEUTICAL COMPOSITIONS

摘要

Compounds of the general formula (I) which are metabolically stable and have an antagonistic activity against PGD2 receptor: <CHEM> wherein Y is bicyclic ring; R<1> is optionally substituted heteroaryl; R<2> is hydrogen, etc.; R<3> is -CH2-CH2-CH2-CH2-CH=CH-COOR<4>, -CH2-CH2-CH2-CH2-X<1>-CH2-COOR<4>, -CH2-CH=CH-CH2-X<1>-CH2-COOR<4> or -CH2-CH2-CH2-CH2-COOR<4>; R<4> is hydrogen, etc.; X<1> is -O-, etc.