发明名称 |
Small particle liposome aerosols for delivery of anti cancer drugs. |
摘要 |
The small particle liposome aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes. The liposomes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration. |
申请公布号 |
ZA200105505(B) |
申请公布日期 |
2003.08.27 |
申请号 |
ZA20010005505 |
申请日期 |
2001.07.04 |
申请人 |
RESEARCH DEVELOPMENT FOUNDATION |
发明人 |
J. VERNON KNIGHT;BRIAN GILBERT;J. CLIFFORD WALDREP;NADEZHDA KOSHKINA;C. W. WELLEN |
分类号 |
A61K9/00;A61K9/12;A61K9/127;A61K31/03;A61K31/175;A61K31/337;A61K31/437;A61K31/4745;A61K31/505;A61K31/513;A61K31/519;A61K31/52;A61K31/525;A61K31/7048;A61K38/21;A61K45/00;A61P35/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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