NOVEL RETINOID DERIVATIVES AND METHODS FOR PREPARATION THEREOF

摘要

PURPOSE: Provided are novel retinoid derivatives and methods for preparation thereof, thereby increasing stability of the retinoid derivatives, allowing them to be easily dispersed, controlling their absorption into the skin and decreasing the skin irritation. CONSTITUTION: Novel retinoid derivatives are characteristically manufactured by covalent bond of retinoid with an aromatic polyester based polymer. The retinoid-polyester copolymer inhibits the inactivation and crystallization of retinoid, therefore, it increases stability of the retinoid derivatives, allows them to be easily dispersed, controls their absorption into the skin and decreases the skin irritation.