发明名称 |
Compositions and methods for modulating RNA |
摘要 |
Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.
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申请公布号 |
US6610663(B2) |
申请公布日期 |
2003.08.26 |
申请号 |
US20010974326 |
申请日期 |
2001.10.10 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
COOK PHILLIP DAN;BRUICE THOMAS;GUINOSSO CHARLES JOHN;KAWASAKI ANDREW MAMORU;GRIFFEY RICHARD |
分类号 |
A61K38/00;A61K48/00;C07H19/04;C07H19/06;C07H19/10;C07H19/16;C07H19/20;C07H21/00;C07H23/00;C07J43/00;C07K14/16;C12N9/02;C12N15/113;C12Q1/68;(IPC1-7):A61K48/00;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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