发明名称 |
Induction of blood vessel formation through administration of polynucleotides encoding sphingosine kinases |
摘要 |
A method of inducing blood vessel formation in an animal by administering to the animal a polynucleotide encoding a sphingosine kinase, or an analogue, fragment, or derivative thereof. The polynucleotide may be contained in an appropriate expression vector, such as a viral vector. The delivery of sphingosine kinase through administration of an expression vector which expresses sphingosine kinase provides for the formation of larger blood vessels containing a well defined structure that is supported by mural cells such as pericytes and smooth muscle cells.
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申请公布号 |
US6610534(B2) |
申请公布日期 |
2003.08.26 |
申请号 |
US20010970516 |
申请日期 |
2001.10.04 |
申请人 |
NOVARTIS AG |
发明人 |
LIAU GENE;STEFANSSON STEINGRIMUR;SU JOSEPH |
分类号 |
C12N15/09;A61K31/7088;A61K35/76;A61K38/00;A61K38/45;A61K48/00;A61P9/00;A61P9/04;A61P9/10;A61P43/00;C12N9/12;(IPC1-7):C12N15/63;A01N43/04;A61K31/70;C07H21/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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地址 |
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