Methods of targeted expression by the CD-RAP gene promoter

摘要

Provided are methods of targeted expression by the cartilage-derived retinoic acid-sensitive protein (CD-RAP) promoter. It is also directed to nucleic acid constructs and vectors useful for expression of nucleic acid sequences targeted to cartilage during development or in adult cartilage tissue, or for their expression in specific tumor cells such as chondrosarcomas and mammary tumor cells. The invention also relates to transgenic animals altered to contain the CD-RAP promoter transgene.