发明名称 |
Salt forms of E-2-Methoxy-N-(3-{4-[3 methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide and method of production |
摘要 |
The invention relates to succinate and malonate complexes of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide having the following formula I: More particular the present invention relates to monosuccinate, hemisuccinate, sesquisuccinate and di-malonate complexes of formula I. The invention also relates to pharmaceutical compositions containing the succinate and malonate complexes of formula I. The invention further relates to methods of treating hyperproliferative diseases, such as cancers, in mammals, especially humans by administering the above complexes and to methods of preparing the above complexes.
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申请公布号 |
US2003158217(A1) |
申请公布日期 |
2003.08.21 |
申请号 |
US20020315862 |
申请日期 |
2002.12.10 |
申请人 |
PFIZER INC. |
发明人 |
KATH JOHN C.;RICHTER DANIEL T.;LI ZHENG J.;TRASK ANDREW V. |
分类号 |
A61K;A61K31/138;A61K31/282;A61K31/337;A61K31/4745;A61K31/475;A61K31/505;A61K31/513;A61K31/517;A61K31/573;A61K31/675;A61K31/704;A61K31/7072;A61K33/24;A61K38/43;A61K39/395;A61K45/00;A61P1/00;A61P1/18;A61P5/00;A61P7/00;A61P11/00;A61P13/02;A61P13/08;A61P13/10;A61P13/12;A61P15/00;A61P17/00;A61P19/00;A61P25/00;A61P27/02;A61P35/00;A61P35/02;A61P43/00;C07D;C07D401/12;(IPC1-7):A61K31/517;C0743/02 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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